About bowen's disease
What is bowen's disease?
Bowen disease is a rare skin disorder. Affected individuals develop a slow-growing, reddish scaly patch or plaque on the skin. Sun exposed areas of the skin are most often affected. Bowen disease only affects the outermost layer of the skin (epidermis). Lesions are usually not painful or may not be associated with any symptoms (asymptomatic). In most cases, treatment is highly successful. Bowen disease is considered a pre-cancerous condition, although the risk of developing skin cancer is less than 10 percent. The disorder usually affects older adults. The exact cause of Bowen disease is unknown, although there are identified risk factors such as chronic sun exposure.
Bowen disease was first described in the medical literature by a physician named JT Bowen in 1912. Bowen disease is also known as squamous cell carcinoma in situ, and is generally considered an early, noninvasive form of intraepidermal squamous cell carcinoma. Intraepidermal means that the disease occurs inside the epidermal layer of the skin.
What are the symptoms for bowen's disease?
Red patches of skin symptom was found in the bowen's disease condition
Typically, Bowen disease appears as a slow-growing, persistent reddish-brown patch or plaque of dry, scaly skin. These lesions may be flat or slightly raised. The lesions are normally not associated with any symptoms, but, occasionally, can itch, ooze pus (if infected), bleed or become crusted and/or tender. In some cases, the lesions may be warty (verrucous), split open (fissured) or, less often, darkly colored (pigmented). In most cases, there is only one lesion, but in approximately 10-20 percent of individuals multiple lesions may develop usually in more than one area of the body.
Although Bowen disease occurs most often on sun exposed areas of the skin, it can develop anywhere on the body, even areas of the skin that are not usually exposed to the sun. The disorder most often develops on the lower legs. Less commonly, the head, neck, palms, soles and genitals can be affected. The lesions can measure anywhere from a few millimeters to a few centimeters.
Individuals with Bowen disease are at risk of developing skin cancer. The risk is estimated to be less than 10 percent, but can be higher in individuals with a compromised immune system. Early signs of cancerous transformation in Bowen disease include the development of a fleshy nodule or bump in a skin lesion. This nodule may be tender and bleed easily. Ulceration or hardening (induration) of a skin lesion also indicates malignant transformation.
Bowen disease is classified as an early, noninvasive form of squamous cell carcinoma, a type of skin cancer that most often occurs on sun damage areas of the skin. Squamous cell carcinoma is the second most common form of skin cancer.
What are the causes for bowen's disease?
The exact cause of Bowen disease is unknown. Chronic sun exposure and aging are believed to be two major risk factors for developing the disorder. Individuals with fair skin and individuals who spend a lot of time outdoors in the sun are at a greater risk of developing Bowen disease. Individuals who take drugs to suppress the immune system (usually taken to treat an immune system disorder) are also at a greater risk than the general population of developing Bowen disease.
Individuals who have cutaneous human papillomavirus (HPV) infection are at risk of developing Bowen disease. Human papilloma viruses are a group of more than 150 related viruses, some of which can cause cancer. HPV 16, 18, 34, and 48 have caused Bowen disease at genital sites. HPV 16 is most commonly associated with the development of Bowen disease. HPV 16 is also the cause of some cases of cervical cancer. Less often, HPV types 2, 16, 34, and 35 are associated with Bowen disease in areas of the body other than the genitals.
Chronic exposure to arsenic appears to be a risk factor for the development of Bowen disease as well. Arsenic is a tasteless, colorless metal element. Arsenic has many uses in manufacturing and other commercial uses. According to the medical literature, chronic exposure to arsenic can cause Bowen disease, approximately 10 years or so after initial exposure. In the past, arsenic was known to have contaminated well water and was once used in various medical preparations. Arsenic exposure occurs far less often today than it did in the past.
What are the treatments for bowen's disease?
There is no specific, definitive treatment for Bowen's disease. Several different therapies may be used all of which have excellent success rates. The specific treatment for an individual case depends upon numerous factors, such as the site of the body affected; the size, thickness and number of the lesion(s); the presence or absence of certain symptoms; an individual’s age and general health; and/or additional elements. Decisions concerning the use of particular drug regimens and/or other treatments should be made by physicians and other members of the health care team in careful consultation with the patient based upon the specifics of his or her case; a thorough discussion of the potential benefits and risks, including possible side effects and long-term effects; patient preference; and other appropriate factors.
A wide variety of treatment options exist for individuals with Bowen disease including topical chemotherapy, cryotherapy, curettage, photodynamic therapy and surgery. Most therapies have an excellent response rate and the prognosis of Bowen disease in most cases is excellent. The response to a particular therapy may vary – what works for one person may be less effective in another. A treatment plan for Bowen disease will be tailored to a patient based on what is best for his or her individual case.
Some individuals may opt for no treatment (watch and wait). Watch and wait refers to when physicians follow a patient with a slow-growing disorder without giving treatment until progression of the disease occurs. This allows some people to avoid undergoing such therapies for many years. Elderly patients with a slow growing lesion in an area where healing may be poor (e.g., lower leg) are candidates for watch and wait.
Topical chemotherapy involves the application of creams applied directly to the lesion. Two common topical medications used to treat Bowen disease are 5-fluorouracil and imiquimod 5%. These treatments may be used alone or in conjunction with other therapies. 5-fluorouracil works by destroying the abnormal skin cells. Generally, affected individuals apply the cream once or twice daily for at least two weeks if not much longer.
Imiquimod 5% is generally used for lesions on the lower legs, larger lesions and the erythroplasia of Queyrat variant of Bowen disease.
Many individuals with Bowen disease may opt for surgical removal of a lesion. Straightforward surgical removal in which the lesion is cut out and the wound is closed by sutures may be used. Surgical removal of a lesion is highly successful, but will leave a surgical scar.
A specific type of surgery called Mohs micrographic surgery is usually not required, but occasionally may be recommended for some individuals with Bowen disease, especially those with larger lesions, recurrent lesions on the head and neck or lesions that are located on areas that require as much preservation of the tissue as possible, e.g. around the nail. With this surgery, a surgeon uses a precise technique to remove the diseased tissue one layer at a time. According to the medical literature, Mohs surgery has the highest cure rate of all treatment options.
Cryotherapy may also be used to treat Bowen disease. Cryotherapy is the use of extreme cold to freeze and destroy the tissue and cells of skin lesions. Cryotherapy is a minimally invasive treatment option. With cryotherapy a freezing substance such as liquid nitrogen or argon gas is applied directly to the lesion. Cryotherapy is most effective for single or small lesions.
Another surgical procedure used to treat individuals with Bowen disease is curettage with cautery/electrocautery. With curettage, the lesion is scraped off the skin. The procedure is usually performed under anesthesia. In some cases, curettage may be followed by cauterization, in which the lesion is burned by an electrical charge. This procedure may need to be repeated in some cases and will often leave a small white scar.
Photodynamic therapy, a procedure in which a drug known as a photosensitizer is used along with a special type of red light, to treat some individuals with Bowen disease who have large or multiple lesions. During photodynamic therapy, the drug is administered to an affected individual and absorbed by the affected cells. A specific wavelength of light is used to activate the drug which binds with oxygen creating a chemical that destroys the affected cells.
In the past, x-ray or radiation therapy (radiotherapy) was often used to treat individuals with Bowen disease, especially individuals who were poor candidates for surgery or who had multiple lesions. Individuals with lesions on the legs are not recommended for radiotherapy because of poor wound healing in that area. Radiotherapy is used less often for the treatment of Bowen disease today than it was in the past.
The most important step to take to lower the risk of Bowen disease is to limit or avoid excess exposure to the sun. Protective clothing, sunscreen, avoiding tanning beds and other measures can be taken to lower the risk of developing Bowen disease.
What are the risk factors for bowen's disease?
Women are more likely to develop agranulocytosis than men are. It can occur at any age. However, inherited forms of the condition are more often found in children, who usually pass away from this condition well before reaching adulthood. Acquired agranulocytosis occurs most frequently in older adults.